Rheumatoid Arthritis: New Findings on the Failure to Isolate or Detect Mycoplasmas by Multiple Cultivation or Serologic Procedures and a Review of the Literature
Identifieur interne : 002F13 ( Main/Exploration ); précédent : 002F12; suivant : 002F14Rheumatoid Arthritis: New Findings on the Failure to Isolate or Detect Mycoplasmas by Multiple Cultivation or Serologic Procedures and a Review of the Literature
Auteurs : Michael F. Barile [États-Unis] ; Hiroshi Yoshida ; Henry RothSource :
- Reviews of Infectious Diseases [ 1058-4838 ] ; 1991.
Abstract
Using 12 different and elaborate broth, agar, and cell culture procedures, we failed to isolate mycoplasmas, ureaplasmas, spiroplasmas, or chlamydiae from the synovial fluid of 10 patients with rheumatoid arthritis (RA) and from six patients with non-rheumatoid arthritis (NRA). In addition, sera from 35 patients with RA and 12 patients with NRA also were examined. Although some of the sera had moderately high titers of metabolism-inhibiting antibody to some of the 10 human Mycoplasma species, especially to the common respiratory pathogen Mycoplasma pneumoniae, and to some of the eight Ureaplasma urealyticum serovars, especially serovars V and VII, there were no significant differences between titers of these antibodies in the two groups of patients. Among RA patients serum antibody titers to M. pneumoniae were 1:32 in five and 1:16 in eight; two patients had higher synovial fluid titers (1:16) than serum titers (1:4). The geometric mean titer (GMT) of antibody to serovar V in synovial fluid was higher in RA patients than in NRA patients, but the difference did not reach significance (P = .056). Reports on the possible role of infectious agents in the pathogenesis of rheumatoid arthritis are reviewed.
Url:
DOI: 10.1093/clinids/13.4.571
Affiliations:
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Barile</name><affiliation></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Reprints and correspondence: Dr. Michael F. Barile, Laboratory of Mycoplasma, Division of Bacterial Products, Center for Biologics Evaluation and Research, Food and Drug Administration, 8800 Rockville Pike, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Yoshida, Hiroshi" sort="Yoshida, Hiroshi" uniqKey="Yoshida H" first="Hiroshi" last="Yoshida">Hiroshi Yoshida</name><affiliation></affiliation><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Roth, Henry" sort="Roth, Henry" uniqKey="Roth H" first="Henry" last="Roth">Henry Roth</name><affiliation><wicri:noCountry code="subField">D.C.</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Reviews of Infectious Diseases</title><title level="j" type="abbrev">Reviews of Infectious Diseases</title><idno type="ISSN">1058-4838</idno><idno type="eISSN">1537-6591</idno><imprint><publisher>The University of Chicago Press</publisher><date when="1991-07">1991</date><biblScope unit="vol">13</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="571">571</biblScope><biblScope unit="page" to="582">582</biblScope></imprint><idno type="ISSN">1058-4838</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1058-4838</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Using 12 different and elaborate broth, agar, and cell culture procedures, we failed to isolate mycoplasmas, ureaplasmas, spiroplasmas, or chlamydiae from the synovial fluid of 10 patients with rheumatoid arthritis (RA) and from six patients with non-rheumatoid arthritis (NRA). In addition, sera from 35 patients with RA and 12 patients with NRA also were examined. Although some of the sera had moderately high titers of metabolism-inhibiting antibody to some of the 10 human Mycoplasma species, especially to the common respiratory pathogen Mycoplasma pneumoniae, and to some of the eight Ureaplasma urealyticum serovars, especially serovars V and VII, there were no significant differences between titers of these antibodies in the two groups of patients. Among RA patients serum antibody titers to M. pneumoniae were 1:32 in five and 1:16 in eight; two patients had higher synovial fluid titers (1:16) than serum titers (1:4). The geometric mean titer (GMT) of antibody to serovar V in synovial fluid was higher in RA patients than in NRA patients, but the difference did not reach significance (P = .056). Reports on the possible role of infectious agents in the pathogenesis of rheumatoid arthritis are reviewed.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Maryland</li></region></list><tree><noCountry><name sortKey="Roth, Henry" sort="Roth, Henry" uniqKey="Roth H" first="Henry" last="Roth">Henry Roth</name><name sortKey="Yoshida, Hiroshi" sort="Yoshida, Hiroshi" uniqKey="Yoshida H" first="Hiroshi" last="Yoshida">Hiroshi Yoshida</name></noCountry><country name="États-Unis"><region name="Maryland"><name sortKey="Barile, Michael F" sort="Barile, Michael F" uniqKey="Barile M" first="Michael F." last="Barile">Michael F. Barile</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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